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This pathway activates a conformational change in the extracellular domains of proteins such as fibrinogen or von Willebrand factor, and fibrinogens act as bridges between platelets to generate platelet aggregation 23

This biphasic effect was subsequently replicated with penicillin and Staphylococcus , prompting the scientific community to re-evaluate the fundamental characteristics of biological stress responses

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In: Poonia A., Trajkovska Petkoska A., editors

Teran-Saavedra et al., 2019